Spreading and Reaction in Aquifers Abstract Spreading is a term used to describe the reconfiguration of a chemical plume in an aquifer as a result of spatial variations in groundwater velocity, which can promote chemical and biogeochemical reactions in the subsurface by bringing together initially distant reactants. The spatial velocity variations are caused by aquifer heterogeneity, which produces passive spreading, and by spatially and temporally varying flow boundary conditions, which produces active spreading. This talk will present recent research by my group on the role of the groundwater flow field, through active and passive spreading, on reactive transport of chemicals in both engineered and natural systems.